Spironolactone is primarily used in the treatment of heart failure with reduced ejection fraction (HFrEF), where it has demonstrated significant benefits in reducing mortality and … · Spironolactone is used to treat heart failure, high blood pressure (hypertension), or hypokalemia (low potassium levels in the blood). Spironolactone also treats fluid retention … · Spironolactone is used in combination with other medicines to treat high blood pressure (hypertension) and heart failure. Lowering blood pressure can reduce the risk of … Spironolactone controls high blood pressure, edema, heart failure, and hyperaldosteronism but does not cure these conditions. It may take about 2 weeks or longer before the full effect of … · Find patient medical information for Spironolactone (Aldactone, Carospir) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user … Spironolactone (Aldactone) is a diuretic that treats high blood pressure and heart failure. It also reduces swelling related to heart, kidney or liver disease.