· Caffeine peaks in your blood about 60 minutes after drinking it, and its effects are typically noticeable for four to six hours. Caffeine has a half-life of two to 12 hours, which is affected by factors such as age, genetics, liver health, and pregnancy. · Caffeine stays in your system for up to 10 hours, with peak levels between 15 minutes and two hours. It's recommended that you limit your caffeine intake to less than 400 milligrams per day. · How long does it take for caffeine to leave your body? Caffeine has a half-life (the time it takes to decrease by half) of five hours. That means that after five hours, you should have 50% of the caffeine you originally consumed in your system. · But how long does caffeine stay in your system and can it affect you even hours after consumption? The half life of caffeine is typically around five to six hours but it can be as much as 12... · How Long Does Caffeine Last? You notice the effects of caffeine within 15 minutes. The levels in your bloodstream peak an hour later and remain there for several hours. About 6 hours after you... Learn how long caffeine stays in your body and how it affects you depending on various factors. Find out how to cope with the caffeine jitters and what to do if you have too much caffeine. How long does caffeine stay in your system? Caffeine has a half-life of about 5 hours in most adults [4]. This means that after 5 hours, half of the caffeine you consumed will still be in your system. It typically takes about 10 hours for caffeine to be completely eliminated from your body.